Thermo FAIMS waveform generator (m/n FAIMS Wave) with TCM temperature control module. (TRIGON TTHM200-2 Hydrocarbon Traps) FAIMS adds another dimension of selectivity to LC/MS/MS experiments, providing the additional selectivity that is often required in challenging LC/MS/MS assays. Using FAIMS, only selected ions pass from the ion source to the mass spectrometer. The result is increased selectivity, improved detection limits, and increased throughput.
FAIMS continuously selects and focuses ions at atmospheric pressure using changes that occur in ion behavior when exposed to high electric fields. At low field strengths, the ion mobility is independent of the applied electric field. However, at high electric fields (for example, greater than 2.5 KV/cm) the mobility of an ion changes with electric field strength. These compound-dependent changes in the mobility of an ion at high field relative to low field provide ion selectivity within the FAIMS interface. In the FAIMS system, alternating high and low electric fields are applied to a set of concentrically cylindrical electrodes. Alternating electric fields are supplied via a waveform generator that produces an asymmetric waveform. This asymmetric waveform applies a high electric field, called the dispersion voltage (DV), between the electrodes for a short period of time and then applies a lower electric field for a longer time.
When the FAIMS electrodes are installed on the mass spectrometer, desolvated ions are introduced into the annular region between the two cylindrical electrodes and are carried toward the mass spectrometer by a flow of gas, called the carrier gas. The ions move radially between the electrodes as the result of the applied asymmetric waveform. Because the mobility of the ion during the application of the DV is different than during the low voltage portion of the waveform, ions begin to drift towards one of the two electrodes. If an ion reaches an electrode surface, it is discharged and neutralized. Please contact us for complete used Thermo parts details. (Thermo Scientific high-Field Asymmetric waveform Ion Mobility Sprectrometry (FAIMS) system for TSQ Quantum series and LTQ series mass spectrometers)
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